Toward antiviral strategies that resist viral escape.
نویسندگان
چکیده
We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug design strategy that would hinder the development of drug resistance.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 44 4 شماره
صفحات -
تاریخ انتشار 2000